(5-Acetylthiophen-2-yl)boronic acid → HCID 89802536, compound

HRID 870690Notes

Reaction equation

HRID 870690 reaction equation
Br[C:2]1[N:6]2[N:7]=[C:8]([NH:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:9]=[CH:10][C:5]2=[N:4][CH:3]=1.[C:20]([C:23]1[S:27][C:26](B(O)O)=[CH:25][CH:24]=1)(=[O:22])[CH3:21]>C(N(CC)CC)C>[C:20]([C:23]1[S:27][C:26]([C:2]2[N:6]3[N:7]=[C:8]([NH:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:9]=[CH:10][C:5]3=[N:4][CH:3]=2)=[CH:25][CH:24]=1)(=[O:22])[CH3:21]

Participants

4

Reactant 2

HCID 4143377(5-Acetylthiophen-2-yl)boronic acidHCID 89802525HCID 89802525, compound

Product 1

HCID 89802536HCID 89802536, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The ethyl 4-((3-bromoimidazo[1,2-b]pyridazin-6-yl)amino)butanoate was subjected to Suzuki coupling with (5-acetylthiophen-2-yl)boronic acid, using triethylamine as the base and the procedure described in example 5.6.19 to give 74% yield of the product.

Sources & evidence

ORD record
ord-776ffb0bede843e39364c4d78b04fa57
Source dataset
uspto-grants-2015_03
Patent number
US08969565B2

Reaction notes

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