Potassium Carbonate → HCID 89802515, compound

HRID 870692Notes

Reaction equation

Br[C:2]1[N:6]2[N:7]=[C:8]([NH:11][CH2:12][CH2:13][CH2:14][C:15]([O:17]CC)=[O:16])[CH:9]=[CH:10][C:5]2=[N:4][CH:3]=1.B(O)O.[C:23]([NH:30][CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24].C([O-])([O-])=O.[K+].[K+]>>[C:26]([O:25][C:23]([NH:30][CH2:31][C:32]1[CH:37]=[CH:36][C:35]([C:2]2[N:6]3[N:7]=[C:8]([NH:11][CH2:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16])[CH:9]=[CH:10][C:5]3=[N:4][CH:3]=2)=[CH:34][CH:33]=1)=[O:24])([CH3:29])([CH3:27])[CH3:28]

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 89802525HCID 89802525, compound

HCID 178453046HCID 178453046, compound

Product 1

HCID 89802515HCID 89802515, compound

Procedure

The ethyl 4-((3-bromoimidazo[1,2-b]pyridazin-6-yl)amino)butanoate was subjected to Suzuki coupling with N-Boc-benzyl amine boronic acid, using 4.0 equivalents of K2CO3 as the base and procedure described in example 5.6.19 to give the titled compound.

Sources & evidence

ORD record: ord-fc6e28d7a9ab4ee3b92a72295adc8c8b
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08969565B2

Reaction notes

Loading…