HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 6-Chloro-5-methylpyridazin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (6-Chloro-5-methyl-pyridazin-3-yl)-(2,4-dimethoxy-benzyl)-amine | HCID 86696398 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-Chloro-5-methylpyridazin-3-amine | HCID 12353663 | — |
Reaction Steps
To a solution of (6-chloro-5-methyl-pyridazin-3-yl)-(2,4-dimethoxy-benzyl)-amine from above (680 mg) in DCM (8 ml) was added TFA (8 ml). The resulting solution was allowed to stand for overnight. The mixture was concentrated to give the titled compound which was used directly for next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969565B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-4179f113de524718b26d2b53cccacf59 |
| Source note | uspto-grants-2015_03 |