Trifluoroacetic acid → 6-Chloro-5-methylpyridazin-3-amine

HRID 870696Notes

Reaction equation

HRID 870696 reaction equation
[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH:8]CC2C=CC(OC)=CC=2OC)=[CH:4][C:3]=1[CH3:20].C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH2:8])=[CH:4][C:3]=1[CH3:20]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86696398(6-Chloro-5-methyl-pyridazin-3-yl)-(2,4-dimethoxy-benzyl)-amine

Product 1

HCID 123536636-Chloro-5-methylpyridazin-3-amine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (6-chloro-5-methyl-pyridazin-3-yl)-(2,4-dimethoxy-benzyl)-amine from above (680 mg) in DCM (8 ml) was added TFA (8 ml). The resulting solution was allowed to stand for overnight. The mixture was concentrated to give the titled compound which was used directly for next step.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-4179f113de524718b26d2b53cccacf59
Source dataset
uspto-grants-2015_03
Patent number
US08969565B2

Reaction notes

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