反应详情

The 4-((3-bromoimidazo[1,2-b]pyridazin-6-yl)amino)-2-methylbutan-2-ol was coupled with (4-(aminomethyl)phenyl)boronic acid as described in example 5.6.19 to afford the titled compound in 78% yield. 1H NMR (400 MHz, METHANOL-d4) δ ppm 1.29 (s, 6H) 1.84-1.94 (m, 2H) 3.49-3.58 (m, 2H) 4.24 (s, 2H) 7.25 (d, J=9.85 Hz, 1H) 7.67 (d, J=8.59 Hz, 2H) 7.97 (d, J=9.85 Hz, 1H) 8.22-8.29 (m, 3H); LRMS (ESI) m/e 326.0 [(M+H)+, calcd for C18H23N5O 325.0].