HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-(Aminomethyl)phenyl)boronic acid → 4-((3-(4-(Aminomethyl)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)-2-methylbutan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-(Aminomethyl)phenyl)boronic acid | HCID 2734312 | — |
| Reactant | 4-((3-Bromoimidazo[1,2-b]pyridazin-6-yl)amino)-2-methylbutan-2-ol | HCID 86696408 | — |
| Product | 4-((3-(4-(Aminomethyl)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)-2-methylbutan-2-ol | HCID 86696409 | 78% |
Reaction Steps
The 4-((3-bromoimidazo[1,2-b]pyridazin-6-yl)amino)-2-methylbutan-2-ol was coupled with (4-(aminomethyl)phenyl)boronic acid as described in example 5.6.19 to afford the titled compound in 78% yield. 1H NMR (400 MHz, METHANOL-d4) δ ppm 1.29 (s, 6H) 1.84-1.94 (m, 2H) 3.49-3.58 (m, 2H) 4.24 (s, 2H) 7.25 (d, J=9.85 Hz, 1H) 7.67 (d, J=8.59 Hz, 2H) 7.97 (d, J=9.85 Hz, 1H) 8.22-8.29 (m, 3H); LRMS (ESI) m/e 326.0 [(M+H)+, calcd for C18H23N5O 325.0].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969565B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-a85f4fefdfd24da78df48aa92dd77a54 |
| Source note | uspto-grants-2015_03 |