Hydrochloric Acid → HCID 86696474, compound

HRID 870765Notes

Reaction equation

HRID 870765 reaction equation
[ClH:1].[CH3:2][CH:3]1[CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][CH2:5][N:4]1[C:16]([O:18][CH:19]([CH3:21])[CH3:20])=[O:17]>CO>[ClH:1].[CH3:2][CH:3]1[CH2:8][NH:7][CH2:6][CH2:5][N:4]1[C:16]([O:18][CH:19]([CH3:21])[CH3:20])=[O:17]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86696475HCID 86696475, compound

Product 1

HCID 86696474HCID 86696474, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Concentrated hydrochloric acid (6.0 mL) was added to a solution of 4-tert-butyl 1-isopropyl 2-methylpiperazine-1,4-dicarboxylate (4.2 g, 14.6 mmol) in methanol (250 mL) and allowed to stir at ambient temperature under N2 blanket for 3d. The solution was then evaporated to dryness and the resultant viscous yellow oil triturated in acetone to precipitate a fine white powder which was isolated by filtration, under N2 blanket, to afford 2.0 g. LRMS (ESI) m/z 187.0 [(M+H)]+, calc'd for C9H18N2O2: 186.26.

Workup

  1. customThe solution was then evaporated to dryness
  2. customthe resultant viscous yellow oil triturated in acetone
  3. customto precipitate a fine white powder which
  4. customwas isolated by filtration, under N2 blanket
  5. customto afford 2.0 g

Sources & evidence

ORD record
ord-0a96ba208f00428c9fff8b8fd45ab4df
Source dataset
uspto-grants-2015_03
Patent number
US08969565B2

Reaction notes

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