反应详情

A solution of tert-Butyl 4-(3-chloro-4-cyanoisothiazol-5-yl)phenylcarbamate (4.76 g, 13.38 mmol) in DCM (100 ml) was treated with 10 mL of TFA. The reaction mixture was stirred at RT overnight. Solvent was removed in vacuo. The residue was diluted with water and DCM (100 ml). Layers were separated and the aqueous layer was extracted with DCM×2. The combined organics was washed with brine and dried with MgSO4, filtered, and concentrated. Product was rinsed with Et2O/hexanes and collected by filtration as a bright yellow solid (3.15 g, 94%).

1. customSolvent was removed in vacuo
2. additionThe residue was diluted with water and DCM (100 ml)
3. customLayers were separated
4. extractionthe aqueous layer was extracted with DCM×2
5. washThe combined organics was washed with brine
6. dry with materialdried with MgSO4
7. filtrationfiltered
8. concentrationconcentrated
9. washProduct was rinsed with Et2O/hexanes
10. filtrationcollected by filtration as a bright yellow solid (3.15 g, 94%)