4-(4-Nitroisothiazol-5-yl)morpholine → 5-Morpholinoisothiazol-4-amine

HRID 871043Notes

Reaction equation

HRID 871043 reaction equation
[N+](C1C=NSC=1OC1CCN(C(OC(C)(C)C)=O)CC1)([O-])=O.[N+:23]([C:26]1[CH:27]=[N:28][S:29][C:30]=1[N:31]1[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1)([O-])=O>>[O:34]1[CH2:35][CH2:36][N:31]([C:30]2[S:29][N:28]=[CH:27][C:26]=2[NH2:23])[CH2:32][CH2:33]1

Participants

3

Reactant 2

HCID 712617854-(4-Nitroisothiazol-5-yl)morpholineHCID 86720856Tert-butyl 4-(4-nitroisothiazol-5-yloxy)piperidine-1-carboxylate

Product 1

HCID 867208605-Morpholinoisothiazol-4-amine

Procedure

Following the procedure described in Example 1, and substituting Compound 1C3 in Step (3) with 4-(4-nitroisothiazol-5-yl)morpholine (6C6) (500 mg, 2.32 mmol) the compound 6D8 (300 mg, 1.62 mmol) was obtained.

Workup

  1. customwas obtained

Sources & evidence

ORD record
ord-598ee9e70a2d48438e9f6f74677396b6
Source dataset
uspto-grants-2015_03
Patent number
US08969584B2

Reaction notes

Loading…