Hydrochloric Acid → HCID 86688757, compound

Participants

Reaction Steps

A solution of [1-(2-benzyloxy-5-chloro-benzyl)-5-methyl-1H-pyrazol-3-yloxy]-acetic acid methyl ester, 8, (1.19 g, 2.97 mmol), PtO2 (0.17 g) and conc. HCl (2 ml) in MeOH was stirred under a H2 atmosphere for 3 hours. The catalyst was removed by filtration, the volatiles were removed in vacuo and the crude product was purified on silica to yield [1-(5-chloro-2-hydroxy-benzyl)-5-methyl-1H-pyrazol-3-yloxy]-acetic acid methyl ester, 9.

Provenance & Evidence