Hydrochloric Acid → HCID 86688757, compound

HRID 871049Notes

Reaction equation

HRID 871049 reaction equation
[CH3:1][O:2][C:3](=[O:28])[CH2:4][O:5][C:6]1[CH:10]=[C:9]([CH3:11])[N:8]([CH2:12][C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=2[O:20]CC2C=CC=CC=2)[N:7]=1.Cl>CO.O=[Pt]=O>[CH3:1][O:2][C:3](=[O:28])[CH2:4][O:5][C:6]1[CH:10]=[C:9]([CH3:11])[N:8]([CH2:12][C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=2[OH:20])[N:7]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86688758HCID 86688758, compound

Product 1

HCID 86688757HCID 86688757, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 887MethanolSolvent

Procedure

A solution of [1-(2-benzyloxy-5-chloro-benzyl)-5-methyl-1H-pyrazol-3-yloxy]-acetic acid methyl ester, 8, (1.19 g, 2.97 mmol), PtO2 (0.17 g) and conc. HCl (2 ml) in MeOH was stirred under a H2 atmosphere for 3 hours. The catalyst was removed by filtration, the volatiles were removed in vacuo and the crude product was purified on silica to yield [1-(5-chloro-2-hydroxy-benzyl)-5-methyl-1H-pyrazol-3-yloxy]-acetic acid methyl ester, 9.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe volatiles were removed in vacuo
  3. customthe crude product was purified on silica

Sources & evidence

ORD record
ord-03529796b6b0493ca4ce85a7c8fc3c96
Source dataset
uspto-grants-2015_03
Patent number
US08969589B2

Reaction notes

Loading…