Sodium Hydroxide → HCID 3337053, compound

HRID 871064Notes

Reaction equation

HRID 871064 reaction equation
[O-][Mn](=O)(=O)=O.[K+].[OH:7][CH:8]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[N+:18]([O-:20])=[O:19])[C:9]([OH:11])=[O:10].[OH-].[Na+]>O>[N+:18]([C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[C:8](=[O:7])[C:9]([OH:11])=[O:10])([O-:20])=[O:19]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 516875Potassium PermanganateHCID 19044915HCID 19044915, compound

Product 1

HCID 3337053HCID 3337053, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

KY-780-batch B KMnO4 (0.168 gr) was added to the cooled (ice water) solution of 2-hydroxy-2-(2-nitrophenyl)acetic acid (0.3 gr, 4.1 mmol), NaOH (70 mg) in water 6 ml. the mixture reaction was stirred for 2 h at 0° c. The mixture reaction was concentrated in vacuum and The residue was purified on C18-reversed phase flash chromatography column employing a linear gradient of 0-30% A in B (flow-rate 40 mL/min), where A is 0.1% formic acid in CH3CN and B is 0.1% of formic acid in water, yielding 80 mg (10%) of pure KY-780-batch B

Workup

  1. customthe mixture reaction
  2. customThe mixture reaction
  3. concentrationwas concentrated in vacuum
  4. customThe residue was purified on C18-reversed phase flash chromatography column
  5. customyielding 80 mg (10%) of pure KY-780-batch B

Sources & evidence

ORD record
ord-0398f65737964bf9bad1b34d9b8e0324
Source dataset
uspto-grants-2015_03
Patent number
US08969573B2

Reaction notes

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