Water → HCID 90408941, compound

HRID 871081Notes

Reaction equation

HRID 871081 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[C:5]([N+:16]([O-])=O)=[CH:4][CH:3]=1.O.[H][H]>O1CCCC1.[Ni]>[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[C:5]([NH2:16])=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 962WaterHCID 63705752HCID 63705752, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 90408941HCID 90408941, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A solution of Example 7A (1.057 g, 3.89 mmol) in tetrahydrofuran (1 mL) was added to 50% Raney® nickel in water (335.5 mg, 5.72 mmol) in a pressure bottle. The mixture was stirred under 60 psi hydrogen at room temperature for 13 hours. The mixture was filtered through a polypropylene membrane and concentrated to give the crude title compound which was used without further purification.

Workup

  1. filtrationThe mixture was filtered through a polypropylene membrane
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-1c6408abef3745f79a8cbfcb0fc94a52
Source dataset
uspto-grants-2015_03
Patent number
US08969375B2

Reaction notes

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