3-Fluorobenzylic alcohol → 6-bromo-5-fluoro-1-(3-fluorobenzyl)-1H-indole

HRID 871083Notes

Reaction equation

HRID 871083 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5]O.[Br:10][C:11]1[CH:19]=[C:18]2[C:14]([CH:15]=[CH:16][NH:17]2)=[CH:13][C:12]=1[F:20].BrC1C=C2C(C(C#N)=CN2)=CC=1>>[Br:10][C:11]1[CH:19]=[C:18]2[C:14]([CH:15]=[CH:16][N:17]2[CH2:5][C:4]2[CH:7]=[CH:8][CH:9]=[C:2]([F:1])[CH:3]=2)=[CH:13][C:12]=1[F:20]

Participants

4

Reactant 3

HCID 680083-Fluorobenzylic alcoholHCID 114700676-Bromo-1H-indole-3-carbonitrileHCID 222629226-Bromo-5-fluoroindole

Product 1

HCID 904087746-bromo-5-fluoro-1-(3-fluorobenzyl)-1H-indole

Procedure

The title compound was prepared using the procedure described in Example 3A using 3-fluorobenzyl alcohol and 6-bromo-5-fluoro-1H-indole in place of benzyl alcohol and 6-bromo-1H-indole-3-carbonitrile, respectively. LCMS: 323.8 (M+H)+.

Sources & evidence

ORD record
ord-5bf9c962439341e2aab5259b830cdd92
Source dataset
uspto-grants-2015_03
Patent number
US08969375B2

Reaction notes

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