3-Fluorobenzyl bromide → 6-bromo-5-fluoro-1-(3-fluorobenzyl)-1H-indole-3-carbonitrile

HRID 871105Notes

Reaction equation

HRID 871105 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]#[N:12])=[CH:7][NH:8]2)=[CH:4][C:3]=1[F:13].Br[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=1>>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]#[N:12])=[CH:7][N:8]2[CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=2)=[CH:4][C:3]=1[F:13]

Participants

3

Reactant 2

HCID 680073-Fluorobenzyl bromideHCID 534029576-Bromo-5-fluoro-1H-indole-3-carbonitrile

Product 1

HCID 904084366-bromo-5-fluoro-1-(3-fluorobenzyl)-1H-indole-3-carbonitrile

Procedure

The title compound was prepared as described in Example 28A using 6-bromo-5-fluoro-1H-indole-3-carbonitrile in place of 6-bromo-1H-pyrrolo[3,2-b]pyridine-3-carbonitrile and using 1-(bromomethyl)-3-fluorobenzene in place of 4-(bromomethyl)tetrahydro-2H-pyran.

Sources & evidence

ORD record
ord-9bd0e3eaedbd42c7a663b029a6160550
Source dataset
uspto-grants-2015_03
Patent number
US08969375B2

Reaction notes

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