化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Cinacalcet Hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Cinacalcet | HCID 156419 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Heptane | HCID 8900 | — |
| 生成物 | Cinacalcet Hydrochloride | HCID 156418 | 92.55% |
反応手順
Cinacalcet base Compound of formula (I) (5.0 gm) was dissolved in toluene (25 ml) and n-heptane (75 ml), and the pH of the solution was adjusted to 1-2 using concentrated hydrochloric acid at 25-30° C. and stirred for 30 minutes. The precipitated solid was filtered, washed with 10 ml n-heptane, and dried under vacuum to yield 5.1 gm (92.55%) of Cinacalcet hydrochloride; HPLC purity 99.80%; chiral purity: 99.95%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08969623B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-792fc4eab3a7433dbc75b753eaab9a78 |
| 出典メモ | uspto-grants-2015_03 |