反应详情

Cinacalcet base Compound of formula (I) (5.0 gm) was dissolved in toluene (25 ml) and n-heptane (75 ml), and the pH of the solution was adjusted to 1-2 using concentrated hydrochloric acid at 25-30° C. and stirred for 30 minutes. The precipitated solid was filtered, washed with 10 ml n-heptane, and dried under vacuum to yield 5.1 gm (92.55%) of Cinacalcet hydrochloride; HPLC purity 99.80%; chiral purity: 99.95%.

1. filtrationThe precipitated solid was filtered
2. washwashed with 10 ml n-heptane
3. customdried under vacuum