Alendronic Acid → 137504-90-6

HRID 871801Notes

Reaction equation

HRID 871801 reaction equation
[CH2:1]([CH2:13][NH2:14])[CH2:2][C:3]([P:9]([OH:12])([OH:11])=[O:10])([P:5]([OH:8])([OH:7])=[O:6])[OH:4].[OH-].[Na+].[Cl-].[Ca+2:18].[Cl-]>>[CH2:1]([CH2:13][NH2:14])[CH2:2][C:3]([P:5]([O-:7])([OH:8])=[O:6])([P:9]([OH:12])([OH:11])=[O:10])[OH:4].[CH2:1]([CH2:13][NH2:14])[CH2:2][C:3]([P:5]([O-:7])([OH:8])=[O:6])([P:9]([OH:12])([OH:11])=[O:10])[OH:4].[Ca+2:18]

Participants

4

Reactant 3

HCID 2088Alendronic AcidHCID 14798Sodium HydroxideHCID 5284359Calcium Chloride2×

Product 1

HCID 178397137504-90-6

Procedure

To the alendronate solution, sodium hydroxide and calcium chloride solutions were simultaneously added to keep the pH of the solution at 7.0 until all the calcium chloride solution had been added. The precipitate was collected by filtration and washed with water. The solid was dried in an oven at 120° C. over night to obtain 1.5 g of alendronate calcium, denoted as CakY (where Y is the Alendronate anion). The mean value of k for the generated alendronate calcium at neutral solution (the pH of human blood) was 1.5±0.1. Chemically, Ca1.5Y corresponds to Ca3Y2. The solubility of Ca1.5Y in saline, as alendronic acid, was measured as 247 mcg/mL or 0.0247%.

Workup

  1. additionhad been added
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water
  4. customThe solid was dried in an oven at 120° C. over night

Sources & evidence

ORD record
ord-f378ccf36d9a48fda3883c5bb8c00522
Source dataset
uspto-grants-2015_03
Patent number
US08974801B2

Reaction notes

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