反应详情

3.0 g (12.04 mmol) of the product prepared in step 8.1 in 40 mL of ethyl acetate are placed in a hydrogenation autoclave, and 0.15 g of 10% palladium-on-charcoal are added, under an inert atmosphere. The mixture is stirred at a hydrogen pressure of 5 bar at room temperature. After filtering through Celite and evaporating under reduced pressure, 1.6 g of the expected product are obtained in the form of a beige-coloured solid, which is used as obtained in the following step. Yield=61%.

1. additionare added, under an inert atmosphere
2. filtrationAfter filtering through Celite
3. customevaporating under reduced pressure, 1.6 g of the expected product
4. customare obtained in the form of a beige-coloured solid, which
5. customas obtained in the following step