Hydrochloric Acid → HCID 70926138, compound

HRID 871858Notes

Reaction equation

HRID 871858 reaction equation
[NH2:1][C:2]1[N:34]([CH2:35][CH3:36])[C:6]2[N:7]=[C:8]([NH:11][C:12]3[C:17]([O:18][CH3:19])=[CH:16][C:15]([N:20]4[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21]4)=[CH:14][C:13]=3[F:33])[N:9]=[CH:10][C:5]=2[C:4](=[O:37])[C:3]=1[C:38](=[O:40])[NH2:39].[ClH:41].CCOCC>CO.O1CCOCC1>[ClH:41].[NH2:1][C:2]1[N:34]([CH2:35][CH3:36])[C:6]2[N:7]=[C:8]([NH:11][C:12]3[C:17]([O:18][CH3:19])=[CH:16][C:15]([N:20]4[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]4)=[CH:14][C:13]=3[F:33])[N:9]=[CH:10][C:5]=2[C:4](=[O:37])[C:3]=1[C:38]([NH2:39])=[O:40]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 86673136HCID 86673136, compound

Product 1

HCID 70926138HCID 70926138, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

0.14 g (0.23 mmol) of the product prepared in step 10.4 is suspended in 4 mL of methanol, and 1.15 mL (4.61 mmol) of a 4N solution of hydrogen chloride in dioxane are added. The mixture is stirred at room temperature overnight, and ether is added. The solid is drained by suction, rinsed with pentane and dried in an oven. 0.10 g of the expected product is obtained in the form of a grey powder, which is used as obtained in the following step. Yield (dihydrochloride)=95%.

Workup

  1. washrinsed with pentane
  2. customdried in an oven

Sources & evidence

ORD record
ord-72508411bd344a3d9bbd2c8224bf6400
Source dataset
uspto-grants-2015_03
Patent number
US08975250B2

Reaction notes

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