Chloroethane → HCID 70926503, compound

HRID 871859Notes

Reaction equation

HRID 871859 reaction equation
[NH2:1][C:2]1[N:29]([CH2:30][CH3:31])[C:6]2[N:7]=[C:8]([NH:11][C:12]3[C:17]([O:18][CH3:19])=[CH:16][C:15]([N:20]4[CH2:25][CH2:24][N:23]([CH2:26][CH3:27])[CH2:22][CH2:21]4)=[CH:14][C:13]=3[F:28])[N:9]=[CH:10][C:5]=2[C:4](=[O:32])[C:3]=1[C:33]([NH2:35])=[O:34].CC[Cl:38]>CO.CCOCC>[ClH:38].[NH2:1][C:2]1[N:29]([CH2:30][CH3:31])[C:6]2[N:7]=[C:8]([NH:11][C:12]3[C:17]([O:18][CH3:19])=[CH:16][C:15]([N:20]4[CH2:25][CH2:24][N:23]([CH2:26][CH3:27])[CH2:22][CH2:21]4)=[CH:14][C:13]=3[F:28])[N:9]=[CH:10][C:5]=2[C:4](=[O:32])[C:3]=1[C:33]([NH2:35])=[O:34]

Participants

5

Reactant 2

HCID 6337ChloroethaneHCID 53303771HCID 53303771, compound

Product 1

HCID 70926503HCID 70926503, compoundYield 141.8%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

To a solution of 0.08 g (0.18 mmol) of the product prepared in step 10.6 in 5 mL of methanol is added 0.53 mL (0.53 mmol) of 1.0 M hydrochloric ether. The mixture is stirred for 30 minutes at room temperature and then diluted with ether. The precipitate is drained by suction, rinsed with ether and with pentane, and dried under vacuum. 0.133 g of the expected product is obtained in the form of a beige-coloured solid. Yield (dihydrochloride)=77%. m.p. >260°C. M+H+=485.

Workup

  1. washrinsed with ether and with pentane
  2. customdried under vacuum

Sources & evidence

ORD record
ord-91cae8effb2244c8a63482740c4486c2
Source dataset
uspto-grants-2015_03
Patent number
US08975250B2

Reaction notes

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