Chloroethane → HCID 70926640, compound

HRID 871882Notes

Reaction equation

HRID 871882 reaction equation
[NH2:1][C:2]1[N:28]([CH2:29][C:30]([OH:33])([CH3:32])[CH3:31])[C:6]2[N:7]=[C:8]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([N:18]4[CH2:23][CH2:22][CH:21]([CH2:24][CH3:25])[CH2:20][CH2:19]4)=[CH:14][C:13]=3[O:26][CH3:27])[N:9]=[CH:10][C:5]=2[C:4](=[O:34])[C:3]=1[C:35]([NH2:37])=[O:36].CC[Cl:40]>ClCCl.CO.CCOCC>[ClH:40].[NH2:1][C:2]1[N:28]([CH2:29][C:30]([OH:33])([CH3:32])[CH3:31])[C:6]2[N:7]=[C:8]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([N:18]4[CH2:23][CH2:22][CH:21]([CH2:24][CH3:25])[CH2:20][CH2:19]4)=[CH:14][C:13]=3[O:26][CH3:27])[N:9]=[CH:10][C:5]=2[C:4](=[O:34])[C:3]=1[C:35]([NH2:37])=[O:36]

Participants

5

Reactant 2

HCID 6337ChloroethaneHCID 67326651HCID 67326651, compound

Product 1

HCID 70926640HCID 70926640, compoundYield 102.6%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 21226129Dichloromethane methanolSolvent

Procedure

To a solution of 0.25 g (0.50 mmol) of the product prepared in step 19.3 in 10 mL of a dichloromethane/methanol mixture (4/1) are added 2 mL (2 mmol) of 1.0 M hydrochloric ether. The mixture is stirred for 10 minutes at room temperature and is then diluted with ether. The precipitate is drained by suction, rinsed with ether and with pentane, and dried under vacuum. 0.28 g of the expected product is obtained in the form of a yellow solid. Yield (dihydrochloride)=96%. m.p.=200°C. (decomposition). M+H+=510.

Workup

  1. washrinsed with ether and with pentane
  2. customdried under vacuum

Sources & evidence

ORD record
ord-6120fdb06a874fd7a9955bec614b9100
Source dataset
uspto-grants-2015_03
Patent number
US08975250B2

Reaction notes

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