Chloroethane → HCID 70926394, compound

HRID 871887Notes

Reaction equation

HRID 871887 reaction equation
[NH2:1][C:2]1[N:29]([CH2:30][C:31]([OH:34])([CH3:33])[CH3:32])[C:6]2[N:7]=[C:8]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([CH:18]4[CH2:23][CH2:22][N:21]([CH:24]5[CH2:26][CH2:25]5)[CH2:20][CH2:19]4)=[CH:14][C:13]=3[O:27][CH3:28])[N:9]=[CH:10][C:5]=2[C:4](=[O:35])[C:3]=1[C:36]([NH2:38])=[O:37].CC[Cl:41]>C(Cl)Cl.CCOCC>[ClH:41].[NH2:1][C:2]1[N:29]([CH2:30][C:31]([OH:34])([CH3:33])[CH3:32])[C:6]2[N:7]=[C:8]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([CH:18]4[CH2:19][CH2:20][N:21]([CH:24]5[CH2:25][CH2:26]5)[CH2:22][CH2:23]4)=[CH:14][C:13]=3[O:27][CH3:28])[N:9]=[CH:10][C:5]=2[C:4](=[O:35])[C:3]=1[C:36]([NH2:38])=[O:37]

Participants

5

Reactant 2

HCID 6337ChloroethaneHCID 67325750HCID 67325750, compound

Product 1

HCID 70926394HCID 70926394, compoundYield 82.7%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a suspension of 0.137 g (0.26 mmol) of the product prepared in step 21.1 in 5 mL of CH2Cl2 are added 1.05 mL (1.05 mmol) of 1.0 M hydrochloric ether. The mixture is stirred for 5 minutes at room temperature and then diluted with ether. The precipitate is drained by suction, rinsed with ether and with pentane, and dried under vacuum. 0.12 g of the expected product is obtained in the form of a yellow solid. Yield (dihydrochloride)=77%. m.p.=206°C. (decomposition). M+H+=568

Workup

  1. washrinsed with ether and with pentane
  2. customdried under vacuum

Sources & evidence

ORD record
ord-04b7741a9e2e4756a506faa73394f1df
Source dataset
uspto-grants-2015_03
Patent number
US08975250B2

Reaction notes

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