反应详情

温度

50 °C

To a solution of 4-cyano-4-methyl-piperidine-1-carboxylic acid tert-butyl ester (2.24 g, 10 mmol) in methanol (25 mL) was added DMSO (1 mL), aqueous 1N NaOH (12 mL, 12 mmol) and H2O2 (4 mL) at room temperature. The mixture was heated at 50° C. for 3 hours. After cooling to room temperature, the mixture was partitioned between EtOAc and H2O. The organic layer was washed successively with H2O and brine. After drying (Na2SO4), the solvent was removed to afford the desired product.

1. temperatureAfter cooling to room temperature
2. customthe mixture was partitioned between EtOAc and H2O
3. washThe organic layer was washed successively with H2O and brine
4. dry with materialAfter drying (Na2SO4)
5. customthe solvent was removed