Hydrochloric Acid → HCID 66911027, compound

HRID 871926Notes

Reaction equation

HRID 871926 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([F:31])([C:14]2[S:15][C:16]([CH2:19][O:20][C:21]3[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:23][CH:22]=3)=[CH:17][N:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:32]>CO.O1CCOCC1>[ClH:32].[F:31][C:11]1([C:14]2[S:15][C:16]([CH2:19][O:20][C:21]3[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:23][CH:22]=3)=[CH:17][N:18]=2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57986836HCID 57986836, compound

Product 1

HCID 66911027HCID 66911027, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 4-fluoro-4-[5-(4-methanesulfonyl-phenoxymethyl)-thiazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (Example 89, 1.30 g, 2.76 mmol) in methanol (5 mL) was added 4 N HCl in dioxane (10 mL). The resulting solution was stirred overnight. The mixture was then evaporated to dryness in vacuo to afford the desired product as a white solid.

Workup

  1. customThe mixture was then evaporated to dryness in vacuo

Sources & evidence

ORD record
ord-0fbc5afa4840425e8eab24cefde542ee
Source dataset
uspto-grants-2015_03
Patent number
US08975258B2

Reaction notes

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