Hydrochloric Acid → 1-[4-(4-Methanesulfonyl-phenoxymethyl)-thiazol-2-yl]-piperazine hydrochloride

HRID 871932Notes

Reaction equation

HRID 871932 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][CH:16]=[C:17]([CH2:19][O:20][C:21]3[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:23][CH:22]=3)[N:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:31]>CO.O1CCOCC1>[ClH:31].[CH3:30][S:27]([C:24]1[CH:23]=[CH:22][C:21]([O:20][CH2:19][C:17]2[N:18]=[C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[S:15][CH:16]=2)=[CH:26][CH:25]=1)(=[O:29])=[O:28]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 250265144-[4-(4-Methanesulfonyl-phenoxymethyl)-thiazol-2-yl]-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 669109741-[4-(4-Methanesulfonyl-phenoxymethyl)-thiazol-2-yl]-piperazine hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 4-[4-(4-Methanesulfonyl-phenoxymethyl)-thiazol-2-yl]-piperazine-1-carboxylic acid tert-butyl ester (Example 91, 430 mg, 0.95 mmol) in methanol (5 mL) was added 4 N HCl in dioxane (5 mL). The resulting solution was stirred for 30 minutes at room temperature. The mixture was then evaporated to dryness in vacuo to afford the desired product as a pale yellow solid.

Workup

  1. customThe mixture was then evaporated to dryness in vacuo

Sources & evidence

ORD record
ord-3ae4e651e80c486f808d65f2ce05ac7d
Source dataset
uspto-grants-2015_03
Patent number
US08975258B2

Reaction notes

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