Hydrochloric Acid → HCID 68928386, compound

HRID 872001Notes

Reaction equation

HRID 872001 reaction equation
C(OC([NH:8][CH2:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[C:28]([CH2:29][O:30][C:31]3[CH:36]=[C:35]([F:37])[CH:34]=[CH:33][C:32]=3[CH3:38])=[C:27]3[C:22]([NH:23][C:24]([CH3:42])([CH3:41])[C:25](=[O:40])[N:26]3[CH3:39])=[CH:21][CH:20]=2)=[C:15]([O:43][CH3:44])[CH:14]=1)=[O:11])=O)(C)(C)C.[ClH:45]>O1CCOCC1.CCCCCC>[ClH:45].[NH2:8][CH2:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[C:28]([CH2:29][O:30][C:31]3[CH:36]=[C:35]([F:37])[CH:34]=[CH:33][C:32]=3[CH3:38])=[C:27]3[C:22]([NH:23][C:24]([CH3:42])([CH3:41])[C:25](=[O:40])[N:26]3[CH3:39])=[CH:21][CH:20]=2)=[C:15]([O:43][CH3:44])[CH:14]=1)=[O:11]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57671819HCID 57671819, compound

Product 1

HCID 68928386HCID 68928386, compoundYield 83%

Reagents, catalysts & solvents 2

HCID 8058HexaneSolventHCID 312751,4-DioxaneSolvent2×

Procedure

7-(4-tert-Butoxycarbonylaminoacetylamino-2-methoxyphenyl)-8-(5-fluoro-2-methylphenoxymethyl)-1,3,3-trimethyl-3,4-dihydro-1H-quinoxalin-2-one (Compound No. 15-31, 10.5 mg, 0.0173 mmol) was dissolved in 1,4-dioxane (0.2 mL), 4N 1,4-dioxane solution of hydrochloride (41.3 μL, 0.165 mmol) was added thereto. After the reaction mixture was stirred for 4 hours at room temperature, it was diluted with hexane (10 mL). The precipitated solid was filtered to give the titled compound (7.8 mg) as a pale yellow solid. (Yield 83%)

Workup

  1. filtrationThe precipitated solid was filtered

Sources & evidence

ORD record
ord-18fd4ed2ea6346f7b0007ecd7dde477e
Source dataset
uspto-grants-2015_03
Patent number
US08975256B2

Reaction notes

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