反应详情

温度

100 °C

A mixture of 5-bromo-4-{[(1S,2S)-2-(5-methoxypyridin-2-yl)cyclopropyl]-methoxy}-2-methylpyrimidine (MM3) (235 mg, 0.7 mmol), tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate (296 mg, 1.0 mmol), tripotassium phosphate (285 mg, 1.3 mmol), S-Phos (27.6 mg, 0.07 mmol), and Pd(OAc)2 (7.5 mg, 0.03 mmol) in THF (3.0 mL) and water (0.5 mL) was heated at 100° C. for 14 hours. The reaction mixture was allowed to cool to room temperature. The mixture was then diluted with EtOAc (10 mL), washed with sodium bicarbonate (2 mL) and brine (2 mL), dried over MgSO4, filtered and concentrated in vacuo. The resulting residue was purified by reverse phase chromatography (Waters Sunfire Prep C18 OBD, 5-45% acetonitrile in water with 0.1% TFA modifier) to afford the title compound as a white solid. 1H NMR (500 MHz, DMSO): δ 8.77 (s, 1 H), 8.15-8.13 (m, 2 H), 7.30-7.22 (m, 3 H), 4.50 (dd, J=11.2, 6.9 Hz, 1 H), 4.37 (dd, J=11.3, 7.5 Hz, 1 H), 3.78 (s, 3 H), 3.17 (d, J=5.3 Hz, 1 H), 2.50 (s, 3 H), 2.22 (dt, J=8.5, 4.6 Hz, 1 H), 1.79 (s, 1 H), 1.21-1.16 (m, 1 H), 1.07 (m, 1 H); LRMS m/z (M+H) 338.4 found, 338.2 required.

1. temperatureto cool to room temperature
2. washwashed with sodium bicarbonate (2 mL) and brine (2 mL)
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. customThe resulting residue was purified by reverse phase chromatography (Waters Sunfire Prep C18 OBD, 5-45% acetonitrile in water with 0.1% TFA modifier)