Ethyl Acetate → HCID 136409081, compound

HRID 872129Notes

Reaction equation

HRID 872129 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[C:8]([C:9]2[CH:14]=[CH:13][C:12](OC)=[CH:11][CH:10]=2)=[C:7]([NH2:17])[NH:6][N:5]=1.[F:18][C:19]([F:34])([F:33])[C:20]1[CH:21]=[C:22]([CH2:26][C:27](=O)[C:28](OC)=[O:29])[CH:23]=[CH:24][CH:25]=1.[C:35](OCC)(=O)C>N1C=CC=CC=1>[CH3:1][O:2][CH2:3][C:4]1[C:8]([C:9]2[CH:10]=[CH:11][C:12]([CH3:35])=[CH:13][CH:14]=2)=[C:7]2[NH:17][C:28](=[O:29])[CH:27]=[C:26]([C:22]3[CH:23]=[CH:24][CH:25]=[C:20]([C:19]([F:33])([F:34])[F:18])[CH:21]=3)[N:6]2[N:5]=1

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 14102854HCID 14102854, compoundHCID 178494728HCID 178494728, compound

Product 1

HCID 136409081HCID 136409081, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
95 °C

Procedure

3-(Methoxymethyl)-4-(4-methoxyphenyl)-1H-pyrazol-5-amine (1.4 g, 6.0 mmol) and methyl 3-(trifluoromethyl)phenyloxopropanoate (2.2 g, 1.5 eq) are dissolved in pyridine (10 mL) and stirred at 95° C. for 12 hours under reflux. Upon completion of the reaction, 2.1 g of the target compound is obtained by purification by column chromatography (ethyl acetate 100%).

Workup

  1. temperatureunder reflux
  2. customUpon completion of the reaction

Sources & evidence

ORD record
ord-f7b3271904f44db1812a5dff111e4c93
Source dataset
uspto-grants-2015_03
Patent number
US08975264B2

Reaction notes

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