HRID872159

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cn1nc(-c2cccc(N3Cc4cc(C(C)(C)C)ccc4C3=O)c2CO)cc(Nc2ccncn2)c1=O

HCID56929142

未命名化合物

结构：Cn1nc(Cl)cc(Nc2ccn(C3CN(C(=O)OC(C)(C)C)C3)n2)c1=O

HCID66634723

1-Azetidinecarboxylic acid, 3-[3-[(6-chloro-2,3-dihydro-2-methyl-3-oxo-4-pyridazinyl)amino]-1H-pyrazol-1-yl]-, 1,1-dimethylethyl ester

C16H21ClN6O3

结构：CC(=O)OCc1c(B2OC(C)(C)C(C)(C)O2)cccc1N1Cc2cc(C(C)(C)C)ccc2C1=O

HCID86697936

未命名化合物

PRODUCTS

生成物

结构：Cn1nc(-c2cccc(N3Cc4cc(C(C)(C)C)ccc4C3=O)c2CO)cc(Nc2ccn(C3CN(C(=O)OC(C)(C)C)C3)n2)c1=O

HCID86697938

未命名化合物

PROCEDURE

实验过程

Using the same general procedure as described for the preparation of 103, reaction of 105c (150 mg, 0.394 mmol) with 102f (201 mg, 0.433 mmol) afforded a crude product 105d which was used in the next step without purification.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0286dcedfdbc4ef781dfd82800592641
来源数据集: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08975260B2
来源说明: uspto-grants-2015_03

反应 SMILES

[C:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[C:10](=[O:14])[N:9]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17](C3C=C(NC4C=CN=CN=4)C(=O)N(C)N=3)[C:16]=1[CH2:36][OH:37])[CH2:8]2)([CH3:4])([CH3:3])[CH3:2].Cl[C:39]1[CH:40]=[C:41]([NH:47][C:48]2[CH:52]=[CH:51][N:50]([CH:53]3[CH2:56][N:55]([C:57]([O:59][C:60]([CH3:63])([CH3:62])[CH3:61])=[O:58])[CH2:54]3)[N:49]=2)[C:42](=[O:46])[N:43]([CH3:45])[N:44]=1.C(OCC1C(B2OC(C)(C)C(C)(C)O2)=CC=CC=1N1CC2C(=CC=C(C(C)(C)C)C=2)C1=O)(=O)C>>[C:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[C:10](=[O:14])[N:9]([C:15]1[C:16]([CH2:36][OH:37])=[C:17]([C:39]3[CH:40]=[C:41]([NH:47][C:48]4[CH:52]=[CH:51][N:50]([CH:53]5[CH2:56][N:55]([C:57]([O:59][C:60]([CH3:63])([CH3:62])[CH3:61])=[O:58])[CH2:54]5)[N:49]=4)[C:42](=[O:46])[N:43]([CH3:45])[N:44]=3)[CH:18]=[CH:19][CH:20]=1)[CH2:8]2)([CH3:4])([CH3:2])[CH3:3]