HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
5-tert-Butyl-2-(2-(hydroxymethyl)-3-(1-methyl-6-oxo-5-(pyrimidin-4-ylamino)-1,6-dihydropyridazin-3-yl)phenyl)isoindolin-1-one → tert-Butyl 3-(3-(6-(3-(5-tert-butyl-1-oxoisoindolin-2-yl)-2-(hydroxy-methyl)phenyl)-2-methyl-3-oxo-2,3-dihydropyridazin-4-ylamino)-1H-pyrazol-1-yl)-azetidine-1-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 5-tert-Butyl-2-(2-(hydroxymethyl)-3-(1-methyl-6-oxo-5-(pyrimidin-4-ylamino)-1,6-dihydropyridazin-3-yl)phenyl)isoindolin-1-one | HCID 56929142 | — |
| Edukt | tert-Butyl 3-(3-(6-Chloro-2-methyl-3-oxo-2,3-dihydropyridazin-4-ylamino)-1H-pyrazol-1-yl)azetidine-1-carboxylate | HCID 66634723 | — |
| Edukt | 2-(5-tert-Butyl-1-oxoisoindolin-2-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl Acetate | HCID 86697936 | — |
| Produkt | tert-Butyl 3-(3-(6-(3-(5-tert-butyl-1-oxoisoindolin-2-yl)-2-(hydroxy-methyl)phenyl)-2-methyl-3-oxo-2,3-dihydropyridazin-4-ylamino)-1H-pyrazol-1-yl)-azetidine-1-carboxylate | HCID 86697938 | — |
Reaktionsschritte
Using the same general procedure as described for the preparation of 103, reaction of 105c (150 mg, 0.394 mmol) with 102f (201 mg, 0.433 mmol) afforded a crude product 105d which was used in the next step without purification.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08975260B2 |
| Quelldatensatz | uspto-grants-2015_03 |
| ORD ID | ord-0286dcedfdbc4ef781dfd82800592641 |
| Quellennotiz | uspto-grants-2015_03 |