反应详情

Following the procedures of Example 109, 148.4 mg (0.36 mmol) of 2-tert-butyl-5-(2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4H-pyrrolo[3,4-d]thiazol-6(5H)-one 109f, 114.6 mg (0.3 mmol) of 6-chloro-4-(5-cyclopropyl-1H-pyrazol-3-ylamino)-2-((2-(trimethylsilyl)ethoxy)methyl)pyridazin-3(2H)-one 111a, 27.5 mg (0.03 mmol) of tris(dibenzylideneacetone)dipalladium(0), 29.6 mg (0.072 mmol) of 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (0.596 mmol), 0.71 mL (0.9 mmol) of 1.27 M of potassium phosphate in water, and 10 mL of 1,4-dioxane to afford 129 mg (68%) of 2-tert-butyl-5-(3-(5-(5-cyclopropyl-1H-pyrazol-3-ylamino)-6-oxo-1-((2-(trimethylsilyl)ethoxy)methyl)-1,6-dihydropyridazin-3-yl)-2-methylphenyl)-4H-pyrrolo[3,4-d]thiazol-6(5H)-one 111b.