Benzoic Acid → N-(1-propyl-1H-tetrazol-5-y1)benzamide

HRID 872256Notes

Reaction equation

HRID 872256 reaction equation
[C:1]([OH:9])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:10]([N:13]1[C:17]([NH2:18])=[N:16][N:15]=[N:14]1)[CH2:11][CH3:12]>C(Cl)Cl.CO.CCN(CC)CC>[CH2:10]([N:13]1[C:17]([NH:18][C:1](=[O:9])[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[N:16][N:15]=[N:14]1)[CH2:11][CH3:12]

Participants

4

Reactant 2

HCID 243Benzoic AcidHCID 2206221-propyl-1H-tetrazol-5-amine

Product 1

HCID 960187N-(1-propyl-1H-tetrazol-5-y1)benzamideYield 54%

Reagents, catalysts & solvents 1

HCID 21913430dichloromethane MeOH Et3NSolvent

Procedure

Employing 0.25 g (2.1 mmol) of benzoic acid and 0.26 g (2.1 mmol) of 1-propyl-1H-tetrazol-5-amine in the procedure described above for Compound F2 and elution with CH2Cl2/MeOH/Et3N (9.8:0.1:0.1) gave the product in 54% yield.

Workup

  1. customgave the product in 54% yield

Sources & evidence

ORD record
ord-f06530311c9b436aa0f82e92cafb3163
Source dataset
uspto-grants-2015_03
Patent number
US08975288B2

Reaction notes

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