Cyclohexylamine → 3-chloro-N-cyclohexylbenzamide

HRID 872264Notes

Reaction equation

HRID 872264 reaction equation
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12](Cl)=[O:13]>>[Cl:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12]([NH:7][CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)=[O:13]

Participants

3

Reactant 2

HCID 7965CyclohexylamineHCID 69252Benzoyl chloride, 3-chloro-

Product 1

HCID 3068243-chloro-N-cyclohexylbenzamideYield 70%

Procedure

Employing 0.19 g (1.9 mmol) of cyclohexylamine and 0.51 g, (2.9 mmol) of 3-chloro-benzoyl chloride in the procedure described above and elution with CHCl3/MeOH/Et3N (9.8:0.1:0.1) gave white crystals in 70% yield.

Workup

  1. washelution with CHCl3/MeOH/Et3N (9.8:0.1:0.1)
  2. customgave white crystals in 70% yield

Sources & evidence

ORD record
ord-388c45c4d0e04b55840efcf5cbffab1e
Source dataset
uspto-grants-2015_03
Patent number
US08975288B2

Reaction notes

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