Cyclopentylamine → 3-chloro-N-cyclopentylbenzamide

HRID 872265Notes

Reaction equation

HRID 872265 reaction equation
[CH:1]1([NH2:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11](Cl)=[O:12]>>[Cl:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11]([NH:6][CH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1)=[O:12]

Participants

3

Reactant 2

HCID 2906CyclopentylamineHCID 69252Benzoyl chloride, 3-chloro-

Product 1

HCID 41244353-chloro-N-cyclopentylbenzamideYield 92%

Procedure

Employing 0.16 g (1.9 mmol) of cyclopentylamine and 0.51 g, (2.9 mmol) of 3-chloro-benzoyl chloride in the procedure described above and elution with CHCl3/MeOH/Et3N (9.8:0.1:0.1) gave white crystals in 92% yield).

Workup

  1. washelution with CHCl3/MeOH/Et3N (9.8:0.1:0.1)
  2. customgave white crystals in 92% yield)

Sources & evidence

ORD record
ord-542791f0f382422f960f4c5e087ed867
Source dataset
uspto-grants-2015_03
Patent number
US08975288B2

Reaction notes

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