反应详情

温度

100 °C

A mixture of crude 5-[4-(2-bromo-2-phenyl-acetyl)-phenyl]-2-oxa-4-aza-bicyclo[3.1.1]heptan-3-one (2.5 g), 4-methoxypyrimidin-2-amine (1.26 g), triethylamine (0.84 mL) and ethanol (62 mL), under argon, was heated at 100° C. (bath temperature) for 6 hours. On cooling the reaction was concentrated and partitioned between EtOAc and water. The aqueous phase was extracted with EtOAc and the combined organic phases were washed with brine, dried and concentrated. Purification was achieved by chromatography on silica gel followed by preparative reverse phase HPLC to give the title compound.

1. temperatureOn cooling the reaction
2. concentrationwas concentrated
3. custompartitioned between EtOAc and water
4. extractionThe aqueous phase was extracted with EtOAc
5. washthe combined organic phases were washed with brine
6. customdried
7. concentrationconcentrated
8. customPurification