Ammonia → HCID 66665345, compound

HRID 872329Notes

Reaction equation

HRID 872329 reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[C:7]([O:38][CH3:39])[C:8]2[N:9]([C:11]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([C:20]4([NH:24][C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:23][CH2:22][CH2:21]4)=[CH:16][CH:15]=3)[N:13]=2)[CH:10]=1)=O.[NH3:40]>CO>[C:28]([O:27][C:25](=[O:26])[NH:24][C:20]1([C:17]2[CH:16]=[CH:15][C:14]([C:12]3[N:13]=[C:8]4[C:7]([O:38][CH3:39])=[CH:6][C:5]([C:3](=[O:2])[NH2:40])=[CH:10][N:9]4[C:11]=3[C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)=[CH:19][CH:18]=2)[CH2:21][CH2:22][CH2:23]1)([CH3:30])([CH3:29])[CH3:31]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 66665411HCID 66665411, compound

Product 1

HCID 66665345HCID 66665345, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-8-methoxy-3-phenyl-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester (200 mg) and a solution of ammonia in methanol (7M, 2.65 mL) was heated at 120° C. for 6 hours under microwave irradiation. On cooling, the reaction mixture was concentrated in vacuo. Purification was achieved by chromatography on silica gel to give the title compound.

Workup

  1. temperatureOn cooling
  2. concentrationthe reaction mixture was concentrated in vacuo
  3. customPurification

Sources & evidence

ORD record
ord-5ca23228065a423c94adb7d4fbeee666
Source dataset
uspto-grants-2015_03
Patent number
US08975265B2

Reaction notes

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