Ammonia → HCID 66665345, compound

Participants

Reaction Steps

A mixture of 2-[4-(1-tert-butoxycarbonylamino-cyclobutyl)-phenyl]-8-methoxy-3-phenyl-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester (200 mg) and a solution of ammonia in methanol (7M, 2.65 mL) was heated at 120° C. for 6 hours under microwave irradiation. On cooling, the reaction mixture was concentrated in vacuo. Purification was achieved by chromatography on silica gel to give the title compound.

Provenance & Evidence