Ammonia → HCID 56644404, compound

HRID 872350Notes

Reaction equation

HRID 872350 reaction equation
C[O:2][C:3]([C:5]1[C:6]2[N:7]([C:11]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([C:20]4([NH2:24])[CH2:23][CH2:22][CH2:21]4)=[CH:16][CH:15]=3)[N:13]=2)[CH:8]=[CH:9][CH:10]=1)=O.[NH3:31]>>[NH2:24][C:20]1([C:17]2[CH:16]=[CH:15][C:14]([C:12]3[N:13]=[C:6]4[C:5]([C:3]([NH2:31])=[O:2])=[CH:10][CH:9]=[CH:8][N:7]4[C:11]=3[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[CH:19][CH:18]=2)[CH2:21][CH2:22][CH2:23]1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 66668165HCID 66668165, compound

Product 1

HCID 56644404HCID 56644404, compound

Conditions

Temperature
130 °C

Procedure

A mixture of 2-[4-(1-amino-cyclobutyl)-phenyl]-3-phenyl-imidazo[1,2-a]pyridine-8-carboxylic acid methyl ester (Example 2-23, 128 mg) and ammonia (2.23 mL of a 7M aqueous solution) was heated at 130° C. under microwave irradiation for 90 minutes. On cooling, the reaction mixture was concentrated to give the title compound.

Workup

  1. temperatureOn cooling
  2. concentrationthe reaction mixture was concentrated

Sources & evidence

ORD record
ord-07eac071550c4b7084ee692c8ef93ed5
Source dataset
uspto-grants-2015_03
Patent number
US08975265B2

Reaction notes

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