反应详情

The crude product from Step 3 (167 mg) was dissolved in EtOH (7 mL) whereupon a precipitate formed which was filtered. The filtrate was hydrogenated using an H-Cube flow reactor (Pd/C cartridge, oven temperature 50° C.). The eluant was collected from the flow reactor in two fractions. The second fraction was concentrated in vacuo and triturated with DCM to give a solid which was filtered and dried to give a further portion of title compound (16 mg).

1. customformed which
2. filtrationwas filtered
3. customan H-Cube flow reactor (Pd/C cartridge, oven temperature 50° C.)
4. customThe eluant was collected from the flow reactor in two fractions
5. concentrationThe second fraction was concentrated in vacuo
6. customtriturated with DCM
7. customto give a solid which
8. filtrationwas filtered
9. customdried