HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178422599, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-{2-[4-(1-Tert-butoxycarbonylamino-cyclobutyl)-phenyl]-3-phenyl-imidazo[1,2-a]pyridin-6-yl}-3-methyl-pyrazole-1-carboxylic acid tert-butyl ester | HCID 66665582 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178422599 | HCID 178422599 | 18.7% |
Reaction Steps
The crude product from Step 1 (79 mg) was dissolved in DCM/MeOH (2 mL/1 mL) and treated with HCl (4 M soln in dioxane, 0.96 mL). The reaction was stirred for 2 hours before it was poured onto ice, made alkaline with dilute aqueous sodium hydroxide solution (2M) and extracted with DCM. The organic phase was washed with brine, dried and concentrated in vacuo. Purification was achieved by chromatography on silica gel to give the title compound (10 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08975265B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-4b79bd4d4d3a4d049abc5b1220e55d5c |
| Source note | uspto-grants-2015_03 |