反应详情

The crude product from Step 1 (79 mg) was dissolved in DCM/MeOH (2 mL/1 mL) and treated with HCl (4 M soln in dioxane, 0.96 mL). The reaction was stirred for 2 hours before it was poured onto ice, made alkaline with dilute aqueous sodium hydroxide solution (2M) and extracted with DCM. The organic phase was washed with brine, dried and concentrated in vacuo. Purification was achieved by chromatography on silica gel to give the title compound (10 mg).

1. additionwas poured onto ice
2. extractionextracted with DCM
3. washThe organic phase was washed with brine
4. customdried
5. concentrationconcentrated in vacuo
6. customPurification