Vinyl Acetate → HCID 25158285, compound

Participants

Reaction Conditions

Reaction Steps

Independently, a mixture (100 ml) of sodium carbonate (0.06 mol) with toluene was raised in temperature to 95° C. While maintaining the temperature at 95° C., 4.2 g of vinyl acetate was added dropwise, and 15 minutes later, di-μ-chlorobis(1,5-cyclooctadiene)diiridium(I) [Ir(cod)Cl]2 (0.5 mmol) was added. Next, 4-(3-ethyloxetan-3-yl-methoxy)cyclohexanol (0.05 mol) was added dropwise over 2 hours, followed by performing a reaction in a nitrogen atmosphere while adding 12.6 g of vinyl acetate dropwise and maintaining the reaction temperature at 95° C. After the completion of the dropwise addition and subsequent stirring for 1 hour, the reaction mixture was analyzed by gas chromatography and found that there was formed 3-ethyl-3-(4-vinyloxycyclohexyloxymethyl)oxetane represented by following formula in a yield of 92%. This was subjected to a 1H-NMR (CDCl3) measurement and found that signals specific to vinyl group were observed at 6.5 ppm, 4.2 ppm, and 4.04 ppm, as in Synthesis Example 1.

Provenance & Evidence