反应详情

2-Amino-2-methyl-1-propanol (4.46 g, 50 mmol) and phthalic anhydride (7.41 g, 50 mmol) were heated at 170° C. for 30 minutes. Icewater was added to the cooled reaction mixture and then the mixture was extracted three times with DCM. Organic phase was dried over Na2SO4, filtered and evaporated to dryness. Crude product was purified by CombiFlash (column: silica, eluent: 0-10% MeOH in DCM) to obtain 3.611 g (33%) of the title compound. LC-MS: M+1=220.

1. additionIcewater was added to the cooled reaction mixture
2. extractionthe mixture was extracted three times with DCM
3. dry with materialOrganic phase was dried over Na2SO4
4. filtrationfiltered
5. customevaporated to dryness
6. customCrude product was purified by CombiFlash (column: silica, eluent: 0-10% MeOH in DCM)