反应详情

Ethyl 2-(1H-imidazol-4-yl)thiazole-4-carboxylate (1.5 g, 6.72 mmol) was dissolved in THF (10 ml). Into the suspension, lithium hydroxyde monohydrate 1M solution (13.44 ml, 13.44 mmol) was added and the resulting mixture was stirred for 4 h. Then 3.36 ml of lithium hydroxyde monohydrate 1M solution was added and the mixture was stirred for another hour. The mixture was evaporated, 10 ml of water added and the pH was adjusted to 1 with concentrated HCl. The precipitate was filtered. Both the filtrate and filtered precipitate contained the product. The filtrate was dissolved in toluene and evaporated twice. LC-MS: [M+1]=196.20.

1. stirringthe mixture was stirred for another hour
2. customThe mixture was evaporated
3. addition10 ml of water added
4. filtrationThe precipitate was filtered
5. filtrationBoth the filtrate and filtered precipitate
6. dissolutionThe filtrate was dissolved in toluene
7. customevaporated twice