反应详情

Methyl 2-(3-hydroxybutan-2-ylamino)thiazole-4-carboxylate (1.092 g, 4.75 mmol) was dissolved in THF/water (9:1) mixture and 1M lithium hydroxide (9.49 ml, 9.49 mmol) was added slowly. The reaction mixture was stirred at RT for 1 h and evaporated to dryness. DCM and water was added and pH was adjusted to 2. Acidic water phase was washed twice with DCM and evaporated to dryness. Evaporation residue was dissolved in ethanol, a precipitation was filtered and the filtrate was evaporated to dryness to give a crude product. m/z [216.3+1].

1. additionwas added slowly
2. customevaporated to dryness
3. additionDCM and water was added
4. washAcidic water phase was washed twice with DCM
5. customevaporated to dryness
6. customEvaporation residue
7. dissolutionwas dissolved in ethanol
8. customa precipitation
9. filtrationwas filtered
10. customthe filtrate was evaporated to dryness