Lithium Hydroxide → HCID 20508424, compound

HRID 872672Notes

Reaction equation

HRID 872672 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[S:6][CH:7]=[C:8]([C:10]([O:12]CC)=[O:11])[N:9]=1)[CH3:3].[OH-].[Li+]>C1COCC1.CO>[CH3:3][N:2]([CH2:4][C:5]1[S:6][CH:7]=[C:8]([C:10]([OH:12])=[O:11])[N:9]=1)[CH3:1]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 2039211Ethyl 2-((dimethylamino)methyl)thiazole-4-carboxylate

Product 1

HCID 20508424HCID 20508424, compound

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

Ethyl 2-((dimethylamino)methyl)thiazole-4-carboxylate (147 mg, 0.686 mmol) was dissolved in THF/methanol mixture (9:1) and 1M lithium hydroxide (1.372 ml, 1.372 mmol) was added slowly. The reaction mixture was stirred at RT for 3 h, pH was adjusted to 2 and the mixture was evaporated to dryness to yield the title compound as a crude product. m/z [186.2+1].

Workup

  1. customthe mixture was evaporated to dryness

Sources & evidence

ORD record
ord-997294fca5d542f88519ce3bf05be65a
Source dataset
uspto-grants-2015_03
Patent number
US08975254B2

Reaction notes

Loading…