HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2,6-dichloro-4-(1H-pyrazol-5-yl)benzonitrile hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole | HCID 11587208 | — |
| Reactant | HCID 15811087 | HCID 15811087 | — |
| Product | 2,6-dichloro-4-(1H-pyrazol-5-yl)benzonitrile hydrochloride | HCID 67172746 | — |
Reaction Steps
The title compound was prepared from 2,6-dichloro-4-iodobenzonitrile (1.09 g, 3.66 mmol) and 1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester (1.32 g, 4.76 mmol) as described in Example 34 (a) and (b) until the isolation of the hydrochloride. Yield 0.824 g. 1H NMR (400 MHz; d6-DMSO): δ 7.07 (d, 1H), 7.88 (d, 1H), 8.14 (s, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08975254B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-2b5be641e0534fd6849d03fd483f32fc |
| Source note | uspto-grants-2015_03 |