反应详情

温度

190 °C

4-(4-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)-2-chlorobenzonitrile (3 g, 8.18 mmol), copper(I) cyanide (0.733 g, 8.18 mmol) and N,N-dimethyl formamide (15 ml) were loaded in a microwave reactor tube. The mixture was heated 190° C. for 5 h. The reaction was quenched by pouring the mixture into 200 ml of 12% ammonia solution and stirred for 30 min. The precipitate was filtered, washed with water and dried in vacuum at 40° C. The product was used in the next step without further purification. LC-MS: [M+1]=313.75.

1. customThe reaction was quenched
2. additionby pouring the mixture into 200 ml of 12% ammonia solution
3. filtrationThe precipitate was filtered
4. washwashed with water
5. customdried in vacuum at 40° C
6. customThe product was used in the next step without further purification