Triethylamine → HCID 67170271, 화합물

HRID 872885노트

반응식

HRID 872885 반응식
[CH3:1][CH2:2][O:3][C:4](/[C:6](/Cl)=[N:7]\[OH:8])=[O:5].[CH3:10][CH:11]([O:15][CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][O:17]1)[CH2:12][C:13]#[CH:14].C(N(CC)CC)C>C(OCC)C>[O:17]1[CH2:18][CH2:19][CH2:20][CH2:21][CH:16]1[O:15][CH:11]([CH3:10])[CH2:12][C:13]1[O:8][N:7]=[C:6]([C:4]([O:3][CH2:2][CH3:1])=[O:5])[CH:14]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 6399471Ethyl 2-chloro-2-(hydroxyimino)acetateHCID 108990812H-Pyran, tetrahydro-2-[(1-methyl-3-butynyl)oxy]-

생성물 1

HCID 67170271HCID 67170271, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

Ethyl chlorooximidoacetate (1 g, 6.60 mmol) and 2-(pent-4-yn-2-yloxy)tetrahydro-2H-pyran (3.33 g, 19.80 mmol) were dissolved in diethyl ether (20 ml) and the mixture was stirred vigorously. Triethylamine (0.920 ml, 6.60 mmol) diluted with diethyl ether was added dropwise. The reaction mixture was extracted with water and the organic phase dried with MgSO4, filtered and evaporated. The product was used in the next step without further purifications. LC-MS: [M+1]=284.32.

후처리

  1. additionwas added dropwise
  2. extractionThe reaction mixture was extracted with water
  3. dry with materialthe organic phase dried with MgSO4
  4. filtrationfiltered
  5. customevaporated

출처 및 근거

ORD 기록
ord-39fca2328ee941cb9b5c7b3a0bcfedc8
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08975254B2

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